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Image Search Results
Journal: Frontiers in Immunology
Article Title: Multi-omics characterization and machine learning of lung adenocarcinoma molecular subtypes to guide precise chemotherapy and immunotherapy
doi: 10.3389/fimmu.2024.1497300
Figure Lengend Snippet: Molecular Landscape and Validation of LUAD Consensus Subtypes (CSs). (A) Enrichment of three subtypes with various treatment-related and bladder cancer-related signatures. (B) Activity profiles of 23 transcription factors (TFs) and potential regulators of chromatin remodeling across the three subtypes. (C) Immune profiles within the TCGA cohort, featuring a heatmap with annotations for immune and stromal enrichment scores, and DNA methylation of tumor-infiltrating lymphocytes. The heatmap includes expression levels of canonical immune checkpoint genes and enrichment levels of 24 tumor immune microenvironment-related immune cells. (D) Validation of LUAD CSs using the nearest template prediction in the META-LUAD cohort. (E) Survival analysis of LUAD CSs within the meta cohort. (F, G) Consistency of CSs with Nearest Template Prediction (NTP) and Prediction Analysis for Microarrays (PAM) in the TCGA cohort. (H) Consistency of NTP with PAM in the meta-cohort.
Article Snippet: Total RNA was isolated from LUAD cells with the AG RNAex Pro Reagent (AG, Changsha, China) and subsequently converted into cDNA using the
Techniques: Biomarker Discovery, Activity Assay, DNA Methylation Assay, Expressing